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Critical Illness-related Corticosteroid Insufficiency

Critical Illness-related Corticosteroid
Autor: Aaron Philippe Toll
Verfügbarkeit: Auf Lager.
Artikelnummer: 714176
ISBN / EAN: 9786138198628

Verfügbarkeit: sofort lieferbar

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Zusatzinformation

  • Autor:
  • Verlag: Alphascript Publishing
  • ISBN / EAN: 9786138198628
  • Bindung: Taschenbuch

Produktbeschreibung

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Critical illness-related corticosteroid insufficiency (CIRCI) is a form of adrenal insufficiency in critically ill patients who have blood corticosteroid levels which are inadequate for the severe stress response they experience. Combined with decreased glucocorticoid receptor sensitivity and tissue response to corticosteroids, this adrenal insufficiency constitutes a negative prognostic factor for intensive care patients.The hypothalamic-pituitary-adrenal axis (HPA axis), in which the hypothalamus and pituitary gland control adrenal secretions, undergoes profound changes during critical illness. Both very high and very low levels of cortisol have been linked to a poor outcome in intensive care patients. It has been suggested that high levels could represent severe stress, whereas low levels are due to blunted cortisol production and response.

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